| Single Season - INTs |
| Rashean Mathis - 06 |
8 |
| Marlon McCree - 02 |
6 |
| Aaron Beasley - 99 |
6 |
| *Reggie Nelson - 07 |
5 |
| Rashean Mathis - 05 |
5 |
| Rashean Mathis - 04 |
5 |
| Donovin Darius - 04 |
5 |
| Deon Figures - 97 |
5 |
| Rashean Mathis - 08 |
4 |
| Gerald Sensabaugh - 08 |
4 |
| Sammy Knight - 07 |
4 |
| Terry Cousin - 05 |
4 |
| Donovin Darius - 99 |
4 | |
|
| Single Game - INTs |
| Rashean Mathis - 06 TEN |
2 |
| Rashean Mathis - 06 PIT |
2 |
| Terry Cousin - 05 BAL |
2 |
| Rashean Mathis - 05 @STL |
2 |
| Donovin Darius - 04 @OAK |
2 |
| Rashean Mathis - 04 @GB |
2 |
| Marlon McCree - 02 @KC |
2 |
| Rayna Stewart - 00 @BAL |
2 |
| Aaron Beasley - 99 SF |
2 |
| Deon Figures - 97 @BAL |
2 |
|
|